Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells
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منابع مشابه
Antimicrobial peptide Brevinin-2R induces the secretion of a pro-inflammatory cytokine in HepG2 cells
Introduction: Antimicrobial peptides as the body's defense strategy play an important role in resistance against infection of microorganism. These peptides are able to modulate the immune and inflammatory processes through the production of defensive molecules. Therefore, the modulatory effects of Brevinin-2R, an antimicrobial peptide extracted from the skin of the frog (Rana ridibunda), was ev...
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We investigated the effects of atorvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on the biogenesis of apolipoprotein B (apoB) in intact and permeabilized HepG2 cells. Intact cells were pretreated either with single or multiple doses of atorvastatin (0.1 to 20 micromol/L) for periods of 6 to 20 hours and pulsed with [35S]methionine. In some cases the cells ...
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Apolipoprotein B (apoB) is the main protein component of very low density lipoprotein (VLDL) and is necessary for the assembly and secretion of these triglyceride (TG)-rich particles. Following release from the liver, VLDL is converted to low density lipoprotein (LDL) in the plasma and increased production of VLDL can therefore play a detrimental role in cardiovascular disease. Increasing evide...
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ژورنال
عنوان ژورنال: Lipids in Health and Disease
سال: 2008
ISSN: 1476-511X
DOI: 10.1186/1476-511x-7-38